Does any PCIe slot support NVMe SSD's automatically or do I need

Nvme drives only connect to pcie bus Even though it'll fit, it won't communicate with sata controller As above, m2 ssd needs to be sata

Oftentimes, slots will support both SATA and NVMe SSDs Make sure to check what SSD technology your motherboard can support

m2 slot 2 M key slots have five pins and support SATA, PCIe, and NVMe protocols They are typically used for high-speed SSDs and other high-performance peripherals

m2 expansion slot 1 x connector , integrated in the Chipset, supporting Socket 3, M key, type 22422260228022110 SSDs