When can I actually unlock the ability to equip artifacts?

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You will unlock the Artifact slot during the main story mission, Cold as the Grave As mentioned above, unlocking the Artifact slot

Borderlands 3_How to get the Artifacts slots unlock ; Borderlands 3 How to get to Mayhem Level Borderlands 3_How to get the Artifacts slots unlock ; Borderlands 3 How to get to Mayhem Level

good girl Do This now for EASY Artifacts in Borderlands 3 Get them Artifacts Borderlands 3 Hope you Your Fourth Weapon Slot will unlock after completing the first vault mission in the main story, Beneath the Meridian, which is the 10th main